LZTS1

Leucine zipper putative tumor suppressor 1. The canonical sequence contains 596 amino acids.

Sequence and protein regions

Explore the LZTS1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median LZTS1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples134.8

Other tumor types438 samples92.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000061337
UniProt accession: Q9Y250
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 596
Sequence SHA-256: 9b7be3df2fd8c9289ad6396363aaca2240281cca7db991584225ca8be77698e4

View and select the full canonical sequence

Canonical amino-acid sequence

MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI

Sequence positions 1–596

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Lipid attachment sites

2–2 (N-myristoyl glycine)

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9Y250

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: LIPID 2; /note="N-myristoyl glycine"; /evidence="ECO:0000250"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Leucine zipper putative tumor suppressor 1
Protein location: Cytoplasm, cell membrane and synapses
Canonical sequence: Q9Y250 · 596 amino acids

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: brain: 24.4; parathyroid gland: 51.0
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: cerebral cortex: 1,108,286.0
Tissue cell-type enrichment: Testis - Sertoli cells
Subcellular location: Plasma membrane

Human Protein Atlas: LZTS1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LZTS1 · ENSG00000061337 · Q9Y250