Surface AtlasMucinous colon cancer

MAS1

Proto-oncogene Mas. UniProt annotates extracellular residues 1–36, 87–104, 173–185, 246–263.

Sequence and protein regions

Explore the MAS1 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median MAS1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors23 samples0.0
Other tumor types258 samples0.0
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000130368
UniProt accession
P04201
Sequence state
available
Canonical sequence
Yes
Length in amino acids
325
Sequence SHA-256
f104c7b186d2a003cfbf9dcad6dcb9e8d9383f5d711634ddd85886324e44bd7a
View and select the full canonical sequence
Sequence positions 1–325

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
37–61: Helical; Name=166–86: Helical; Name=2105–128: Helical; Name=3150–172: Helical; Name=4186–206: Helical; Name=5225–245: Helical; Name=6264–284: Helical; Name=7
37–61 (Helical; Name=1); 66–86 (Helical; Name=2); 105–128 (Helical; Name=3); 150–172 (Helical; Name=4); 186–206 (Helical; Name=5); 225–245 (Helical; Name=6); 264–284 (Helical; Name=7)
Source-annotated domains
1–36: Extracellular62–65: Cytoplasmic87–104: Extracellular129–149: Cytoplasmic173–185: Extracellular207–224: Cytoplasmic246–263: Extracellular285–325: Cytoplasmic
1–36 (Extracellular); 62–65 (Cytoplasmic); 87–104 (Extracellular); 129–149 (Cytoplasmic); 173–185 (Extracellular); 207–224 (Cytoplasmic); 246–263 (Extracellular); 285–325 (Cytoplasmic)
Source-annotated extracellular intervals
1–3687–104173–185246–263
1–36; 87–104; 173–185; 246–263

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
13636
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
fa4172d316521270a3380be098463ab7a1ac88974e73c5d1e8c4b18756e53c95
8710418
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
262a981ce59355b4b9ccf0c15dd18d87aa383220060ade88c9d8111908e88765
17318513
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
336e9ef03b046ea1842849a8fb3fd926d8bf609b2664690a58a6f14966744063
24626318
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
5530cd6f21663b0b88e02184b11894ea0ee6f73ae8680afb734cb47e405ba8fa
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P04201

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000255}.
transmembrane
TRANSMEM 37..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical; Name=7"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..36; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 62..65; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 87..104; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 129..149; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 173..185; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 207..224; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 246..263; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 285..325; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Proto-oncogene Mas
Protein location
Transmembrane protein
Canonical sequence
P04201 · 325 amino acids
Extracellular region
UniProt annotates extracellular residues 1–36, 87–104, 173–185, 246–263.

Expression in normal tissues

RNA specificity
Tissue enriched
RNA distribution
Detected in single
RNA tissue-specific nTPM
brain: 2.0
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Uncertain
Tissue cell-type enrichment
Adipose subcutaneous - Smooth muscle cells

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

MAS1 · ENSG00000130368 · P04201

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