MUC16
Mucin-16. UniProt annotates extracellular residues 1–14451.
Sequence and protein regions
Explore the MUC16 sequence, select annotated regions, and copy a request to continue in Codex.
Open this viewRNA expression in tumor samples
Median MUC16 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.
Mucinous tumors37 samples0.6
Other tumor types438 samples0.9
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
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Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000181143
- UniProt accession
- Q8WXI7
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 14507
- Sequence SHA-256
- 19b25ac9608340021e385b94874ec8a1b50464778c241c5fbafb768813859a9d
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Membrane-spanning segments
14452–14472 (Helical)
Source-annotated domains
1–14451 (Extracellular); 14473–14507 (Cytoplasmic)
Source-annotated extracellular intervals
1–14451
UniProt annotates the following extracellular intervals.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 1 | 14451 | 14451 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- uniprotkb-canonical-record
- Extracted field
- sequence.value
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- Q8WXI7
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
- transmembrane
- TRANSMEM 14452..14472; /note="Helical"; /evidence="ECO:0000255"
- topological_domain
- TOPO_DOM 1..14451; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 14473..14507; /note="Cytoplasmic"; /evidence="ECO:0000305"
- signal_peptide
- Not recorded
- lipidation
- Not recorded
Protein identity and location
- Protein
- Mucin-16
- Protein location
- Transmembrane protein
- Canonical sequence
- Q8WXI7 · 14,507 amino acids
- Extracellular region
- UniProt annotates extracellular residues 1–14451.
Expression in normal tissues
- RNA specificity
- Group enriched
- RNA distribution
- Detected in some
- RNA tissue-specific nTPM
- adipose tissue: 6.5; cervix: 15.0; fallopian tube: 5.5; salivary gland: 5.7
- Protein specificity
- Group enriched
- Protein distribution
- Detected in some
- Immunohistochemistry reliability
- Enhanced
- Protein tissue-specific intensity
- fallopian tube: 37,654.0; salivary gland: 129,166.0
- Tissue cell-type enrichment
- Adipose visceral - Mesothelial cells, Lung - Respiratory ciliated cells, Prostate - Urothelial cells, Testis - Early spermatids, Testis - Late spermatids, Thyroid gland - T-cells
Sources and downloads
MUC16 · ENSG00000181143 · Q8WXI7