Surface AtlasMucinous colon cancer

MUC16

Mucin-16. UniProt annotates extracellular residues 1–14451.

Sequence and protein regions

Explore the MUC16 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median MUC16 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples0.6
Other tumor types438 samples0.9
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000181143
UniProt accession
Q8WXI7
Sequence state
available
Canonical sequence
Yes
Length in amino acids
14507
Sequence SHA-256
19b25ac9608340021e385b94874ec8a1b50464778c241c5fbafb768813859a9d
View and select the full canonical sequence
Sequence positions 1–14507

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
14452–14472: Helical
14452–14472 (Helical)
Source-annotated domains
1–14451: Extracellular14473–14507: Cytoplasmic
1–14451 (Extracellular); 14473–14507 (Cytoplasmic)
Source-annotated extracellular intervals
1–14451
1–14451

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
11445114451
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
e9d873eb4d0dd31f72aff5596fbb063cfc72adac7703d8fb4033cbd2a6913247
Sequence and topology sources
Source role
canonical-sequence
Source
uniprotkb-canonical-record
Extracted field
sequence.value
Source row accession
Not recorded

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Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q8WXI7

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subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
transmembrane
TRANSMEM 14452..14472; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..14451; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 14473..14507; /note="Cytoplasmic"; /evidence="ECO:0000305"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Mucin-16
Protein location
Transmembrane protein
Canonical sequence
Q8WXI7 · 14,507 amino acids
Extracellular region
UniProt annotates extracellular residues 1–14451.

Expression in normal tissues

RNA specificity
Group enriched
RNA distribution
Detected in some
RNA tissue-specific nTPM
adipose tissue: 6.5; cervix: 15.0; fallopian tube: 5.5; salivary gland: 5.7
Protein specificity
Group enriched
Protein distribution
Detected in some
Immunohistochemistry reliability
Enhanced
Protein tissue-specific intensity
fallopian tube: 37,654.0; salivary gland: 129,166.0
Tissue cell-type enrichment
Adipose visceral - Mesothelial cells, Lung - Respiratory ciliated cells, Prostate - Urothelial cells, Testis - Early spermatids, Testis - Late spermatids, Thyroid gland - T-cells

Sources and downloads

MUC16 · ENSG00000181143 · Q8WXI7

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