NECTIN4

Nectin-4. UniProt annotates extracellular residues 32–349.

Sequence and protein regions

Explore the NECTIN4 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median NECTIN4 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples451.4

Other tumor types438 samples303.4

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-NECTIN4
UniProt accession: Q96NY8
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 510
Sequence SHA-256: 47dae33285446c4aba143bab37177a3613fd5469c2e26c63c55b73512ce0b218

View and select the full canonical sequence

Canonical amino-acid sequence

MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Sequence positions 1–510

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–31

Membrane-spanning segments

350–370 (Helical)

Source-annotated domains

32–349 (Extracellular); 371–510 (Cytoplasmic)

Source-annotated extracellular intervals

32–349

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
32	349	318	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 e1b064fb36603a71d861aa80e94ca3df488d309e43c20c86180a888b9963955a Amino-acid sequence for this intervalGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSAS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q96NY8

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; SUBCELLULAR LOCATION: [Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).
transmembrane: TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 32..349; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 371..510; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..31; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Nectin-4
Protein location: Transmembrane protein
Canonical sequence: Q96NY8 · 510 amino acids
Extracellular region: UniProt annotates extracellular residues 32–349.

Expression in normal tissues

Unresolved reason: missing Ensembl gene id
Source error code: missing-ensembl-gene-id

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

NECTIN4 · Q96NY8