NGFR

Tumor necrosis factor receptor superfamily member 16. UniProt annotates extracellular residues 29–250.

Sequence and protein regions

Explore the NGFR sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median NGFR RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples18.7

Other tumor types438 samples22.8

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000064300
UniProt accession: P08138
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 427
Sequence SHA-256: 6ef5b18bd18a89c0240ac8302a4ba5764ebd628e2b740820c561e855a67443b8

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Canonical amino-acid sequence

MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV

Sequence positions 1–427

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–28

Membrane-spanning segments

251–272 (Helical)

Source-annotated domains

29–250 (Extracellular); 273–427 (Cytoplasmic)

Source-annotated extracellular intervals

29–250

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
29	250	222	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 23371390a04c8dded801140db99a745e5e29fee5ab0e0fac975295a5734e4249 Amino-acid sequence for this intervalKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDN

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P08138

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3022937}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:22566094}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
transmembrane: TRANSMEM 251..272; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 29..250; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 273..427; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..28
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Tumor necrosis factor receptor superfamily member 16
Protein location: Transmembrane protein
Canonical sequence: P08138 · 427 amino acids
Extracellular region: UniProt annotates extracellular residues 29–250.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: kidney: 4,872,325.4; ovary: 2,275,637.8
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Lung - Fibroblasts_2, Pituitary gland - Fibroblasts, Skeletal muscle - Fibroblasts
Subcellular location: Nucleoplasm, Plasma membrane

Human Protein Atlas: NGFR

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

NGFR · ENSG00000064300 · P08138