NRG1

Pro-neuregulin-1, membrane-bound isoform. UniProt annotates extracellular residues 20–242.

Sequence and protein regions

Explore the NRG1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median NRG1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples12.4

Other tumor types438 samples11.9

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000157168
UniProt accession: Q02297
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 640
Sequence SHA-256: 7571b2a7d1e56afea59b7555aece78da62c51b2604261693e7ba6419f730b721

View and select the full canonical sequence

Canonical amino-acid sequence

MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV

Sequence positions 1–640

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

243–265 (Helical; Note=Internal signal sequence)

Source-annotated domains

20–242 (Extracellular); 266–640 (Cytoplasmic)

Source-annotated extracellular intervals

20–242

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
20	242	223	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 9338ad1ff10f853778cadc9726ea8373955e243bfe6191e54dd0ce416bb63d9e Amino-acid sequence for this intervalSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKR

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q02297

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: [Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active.; SUBCELLULAR LOCATION: [Neuregulin-1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Nucleus. Note=May be nuclear.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted. Note=Has a signal peptide.; SUBCELLULAR LOCATION: [Isoform 10]: Membrane; Single-pass type I membrane protein. Note=May possess an internal uncleaved signal sequence.
transmembrane: TRANSMEM 243..265; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 20..242; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 266..640; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Pro-neuregulin-1, membrane-bound isoform
Protein location: Transmembrane protein
Canonical sequence: Q02297 · 640 amino acids
Extracellular region: UniProt annotates extracellular residues 20–242.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: liver: 15.9
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Uncertain
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Breast - Breast myoepithelial cells, Lung - Alveolar cells type 1, Prostate - Prostate basal glandular cells, Testis - Early spermatids, Testis - Late spermatids
Subcellular location: Nucleoplasm

Human Protein Atlas: NRG1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

NRG1 · ENSG00000157168 · Q02297