PDCD1LG2

Programmed cell death 1 ligand 2. UniProt annotates extracellular residues 20–220.

Sequence and protein regions

Explore the PDCD1LG2 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median PDCD1LG2 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples20.0

Other tumor types438 samples21.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000197646
UniProt accession: Q9BQ51
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 273
Sequence SHA-256: 8bd3ab2005bd4b7272fd2bdd6d9a89d9886486c367f37c6ea57925fc49ce5dec

View and select the full canonical sequence

Canonical amino-acid sequence

MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI

Sequence positions 1–273

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–19

Membrane-spanning segments

221–241 (Helical)

Source-annotated domains

20–220 (Extracellular); 242–273 (Cytoplasmic)

Source-annotated extracellular intervals

20–220

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
20	220	201	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 875388120f5f782f608d612c2896ef471526b2c6be358bc62dcdf3deb7e2c622 Amino-acid sequence for this intervalLFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9BQ51

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:15253154}.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15253154}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15253154}; Single-pass type I membrane protein {ECO:0000305|PubMed:15340161}.
transmembrane: TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 20..220; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 242..273; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..19; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Programmed cell death 1 ligand 2
Protein location: Transmembrane protein
Canonical sequence: Q9BQ51 · 273 amino acids
Extracellular region: UniProt annotates extracellular residues 20–220.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: lymphoid tissue: 14.3
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Uncertain
Protein tissue-specific intensity: lymphoid tissue: 810,461.1
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Breast - Fibroblasts, Kidney - Endothelial cells, Prostate - Fibroblasts, Skeletal muscle - Fibroblasts
Subcellular location: Cytosol

Human Protein Atlas: PDCD1LG2

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PDCD1LG2 · ENSG00000197646 · Q9BQ51