PROM1

Prominin-1. UniProt annotates extracellular residues 20–108, 179–433, 508–792.

Sequence and protein regions

Explore the PROM1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median PROM1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples1,955.1

Other tumor types438 samples1,528.9

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000007062
UniProt accession: O43490
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 865
Sequence SHA-256: cb68350aedcd637e801a54a16f8c205c920dcde6c9f2c595bcd4a0b56251df77

View and select the full canonical sequence

Canonical amino-acid sequence

MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH

Sequence positions 1–865

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–19

Membrane-spanning segments

109–129 (Helical); 158–178 (Helical); 434–454 (Helical); 487–507 (Helical); 793–813 (Helical)

Source-annotated domains

20–108 (Extracellular); 130–157 (Cytoplasmic); 179–433 (Extracellular); 455–486 (Cytoplasmic); 508–792 (Extracellular); 814–865 (Cytoplasmic)

Source-annotated extracellular intervals

20–108; 179–433; 508–792

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
20	108	89	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 d0af8347ce3eb22f495a95018c33885c07361a147777b81652455707c2279a69 Amino-acid sequence for this intervalGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAG
179	433	255	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 9023775f2234eb653c2c54858c427dd4d68f6d67420a061d15a35bbf477b60b3 Amino-acid sequence for this intervalANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSY
508	792	285	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 54e40f363cbb4e5482630c10311ad1a36192124a7f0dc53cd53d7efadc650394 Amino-acid sequence for this intervalGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLN

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: O43490

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
transmembrane: TRANSMEM 109..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 487..507; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 793..813; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 20..108; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 130..157; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 179..433; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 455..486; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 508..792; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 814..865; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..19; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Prominin-1
Protein location: Transmembrane protein
Canonical sequence: O43490 · 865 amino acids
Extracellular region: UniProt annotates extracellular residues 20–108, 179–433, 508–792.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: retina: 252.8
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: Stomach: 2,084,079.3; salivary gland: 1,494,641.4
Tissue cell-type enrichment: Adrenal gland - Adrenal medulla cells, Lung - Respiratory ciliated cells, Minor Salivary Gland - Minor salivary glandular cells, Skin - Eccrine sweat gland cells, Testis - Early spermatids, Testis - Late spermatids
Subcellular location: Plasma membrane

Human Protein Atlas: PROM1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PROM1 · ENSG00000007062 · O43490