PVR

Poliovirus receptor. UniProt annotates extracellular residues 21–343.

Sequence and protein regions

Explore the PVR sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median PVR RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples1,527.9

Other tumor types438 samples1,808.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000073008
UniProt accession: P15151
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 417
Sequence SHA-256: 5eb997559ad887073abcb0765b50f62dee93750205c4b1387b6b4dda88b9ffe3

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Canonical amino-acid sequence

MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR

Sequence positions 1–417

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–20

Membrane-spanning segments

344–367 (Helical)

Source-annotated domains

21–343 (Extracellular); 368–417 (Cytoplasmic)

Source-annotated extracellular intervals

21–343

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
21	343	323	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 cce916b7f5dc5c9522dd524957fb86dd8c18baf738f6545e809e72a64a23f158 Amino-acid sequence for this intervalWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRN

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P15151

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subcellular_location: SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Beta]: Secreted.; SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
transmembrane: TRANSMEM 344..367; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 21..343; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 368..417; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..20; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Poliovirus receptor
Protein location: Transmembrane protein
Canonical sequence: P15151 · 417 amino acids
Extracellular region: UniProt annotates extracellular residues 21–343.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: heart muscle: 14,418,462.1
Tissue cell-type enrichment: Adrenal gland - Adrenal cortex cells, Minor Salivary Gland - Minor salivary glandular cells, Spleen - Fibroblasts_1
Subcellular location: Nucleoplasm, Vesicles, Plasma membrane

Human Protein Atlas: PVR

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PVR · ENSG00000073008 · P15151