Surface AtlasMucinous colon cancer

RHO

Rhodopsin. UniProt annotates extracellular residues 1–36, 97–110, 174–202, 275–284.

Sequence and protein regions

Explore the RHO sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median RHO RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors23 samples0.0
Other tumor types258 samples0.0
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000163914
UniProt accession
P08100
Sequence state
available
Canonical sequence
Yes
Length in amino acids
348
Sequence SHA-256
b59611b13c3509dcbb28613b8c35f400f97e67788dcf416dce0511a576c347c1
View and select the full canonical sequence
Sequence positions 1–348

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
37–61: Helical; Name=174–96: Helical; Name=2111–133: Helical; Name=3153–173: Helical; Name=4203–224: Helical; Name=5253–274: Helical; Name=6285–309: Helical; Name=7
37–61 (Helical; Name=1); 74–96 (Helical; Name=2); 111–133 (Helical; Name=3); 153–173 (Helical; Name=4); 203–224 (Helical; Name=5); 253–274 (Helical; Name=6); 285–309 (Helical; Name=7)
Source-annotated domains
1–36: Extracellular62–73: Cytoplasmic97–110: Extracellular134–152: Cytoplasmic174–202: Extracellular225–252: Cytoplasmic275–284: Extracellular310–348: Cytoplasmic
1–36 (Extracellular); 62–73 (Cytoplasmic); 97–110 (Extracellular); 134–152 (Cytoplasmic); 174–202 (Extracellular); 225–252 (Cytoplasmic); 275–284 (Extracellular); 310–348 (Cytoplasmic)
Lipid attachment sites
322–322: S-palmitoyl cysteine323–323: S-palmitoyl cysteine
322–322 (S-palmitoyl cysteine); 323–323 (S-palmitoyl cysteine)
Source-annotated extracellular intervals
1–3697–110174–202275–284
1–36; 97–110; 174–202; 275–284

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
13636
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
90510c3636257fe6b134024df29f06216c3da41333ba8e9a7e27af5709109097
9711014
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
dc9e3e77ed8ac30b27b82a52588062427b5de5cea7063aee60722ff8991fe22e
17420229
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
7b20acb0df9e4387fe05e79150e35b938b8d99f8c264f75358ca7b8cbbf629be
27528410
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
6ca00425b1381899506c5d31b1ff77a2e7ace009a00f50214c354cddcaa74cd1
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P08100

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:25664179}; Multi-pass membrane protein {ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425}. Membrane {ECO:0000269|PubMed:12566452, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25664179, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425}; Multi-pass membrane protein {ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. {ECO:0000269|PubMed:25664179}.
transmembrane
TRANSMEM 37..61; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TRANSMEM 74..96; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TRANSMEM 111..133; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TRANSMEM 153..173; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TRANSMEM 203..224; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TRANSMEM 253..274; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TRANSMEM 285..309; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"
topological_domain
TOPO_DOM 1..36; /note="Extracellular"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 62..73; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 97..110; /note="Extracellular"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 134..152; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 174..202; /note="Extracellular"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 225..252; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 275..284; /note="Extracellular"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"; TOPO_DOM 310..348; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425"
signal_peptide
Not recorded
lipidation
LIPID 322; /note="S-palmitoyl cysteine"; /evidence="ECO:0000250|UniProtKB:P02699"; LIPID 323; /note="S-palmitoyl cysteine"; /evidence="ECO:0000250|UniProtKB:P02699"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Rhodopsin
Protein location
Transmembrane protein
Canonical sequence
P08100 · 348 amino acids
Extracellular region
UniProt annotates extracellular residues 1–36, 97–110, 174–202, 275–284.

Expression in normal tissues

RNA specificity
Tissue enriched
RNA distribution
Detected in single
RNA tissue-specific nTPM
retina: 3,767.6
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Enhanced

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

RHO · ENSG00000163914 · P08100

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