ROR1

Inactive tyrosine-protein kinase transmembrane receptor ROR1. UniProt annotates extracellular residues 30–406.

Sequence and protein regions

Explore the ROR1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median ROR1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples24.4

Other tumor types438 samples11.4

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000185483
UniProt accession: Q01973
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 937
Sequence SHA-256: ec6867bc5bacc933a118937a895d4f6d05381eab1f38a3f45a0f957b1f60ec69

View and select the full canonical sequence

Canonical amino-acid sequence

MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL

Sequence positions 1–937

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–29

Membrane-spanning segments

407–427 (Helical)

Source-annotated domains

30–406 (Extracellular); 428–937 (Cytoplasmic)

Source-annotated extracellular intervals

30–406

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
30	406	377	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 969d6fba7235c19796666b5674b944bdbb224e57685cab54cab3c24e01542a28 Amino-acid sequence for this intervalQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILY

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q01973

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27162350}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139}.
transmembrane: TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 30..406; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 428..937; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..29; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Inactive tyrosine-protein kinase transmembrane receptor ROR1
Protein location: Transmembrane protein
Canonical sequence: Q01973 · 937 amino acids
Extracellular region: UniProt annotates extracellular residues 30–406.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: parathyroid gland: 23.1
Protein specificity: Tissue enriched
Protein distribution: Detected in some
Protein tissue-specific intensity: intestine: 8,749,231.6
Tissue cell-type enrichment: Liver - Hepatic stellate cells, Thyroid gland - Fibroblasts

Human Protein Atlas: ROR1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ROR1 · ENSG00000185483 · Q01973