Surface AtlasMucinous colon cancer

SLC1A2

Excitatory amino acid transporter 2. UniProt annotates extracellular residues 65–87, 143–235, 297–317, 412–424, 459–471.

Sequence and protein regions

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RNA expression in tumor samples

Median SLC1A2 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples3.6
Other tumor types438 samples3.3
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000110436
UniProt accession
P43004
Sequence state
available
Canonical sequence
Yes
Length in amino acids
574
Sequence SHA-256
9be4c54332c5ff2a4588d5f6252d037760f1eadab5b8cc22a0f16d28466bcf2d
View and select the full canonical sequence
Sequence positions 1–574

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
45–64: Helical88–108: Helical121–142: Helical236–259: Helical; Name=4269–296: Helical; Name=5318–339: Helical; Name=6385–411: Helical; Name=7472–493: Helical; Name=8
45–64 (Helical); 88–108 (Helical); 121–142 (Helical); 236–259 (Helical; Name=4); 269–296 (Helical; Name=5); 318–339 (Helical; Name=6); 385–411 (Helical; Name=7); 472–493 (Helical; Name=8)
Source-annotated domains
1–44: Cytoplasmic65–87: Extracellular109–120: Cytoplasmic143–235: Extracellular260–268: Cytoplasmic297–317: Extracellular340–344: Cytoplasmic376–384: Cytoplasmic412–424: Extracellular459–471: Extracellular494–574: Cytoplasmic
1–44 (Cytoplasmic); 65–87 (Extracellular); 109–120 (Cytoplasmic); 143–235 (Extracellular); 260–268 (Cytoplasmic); 297–317 (Extracellular); 340–344 (Cytoplasmic); 376–384 (Cytoplasmic); 412–424 (Extracellular); 459–471 (Extracellular); 494–574 (Cytoplasmic)
Lipid attachment sites
38–38: S-palmitoyl cysteine
38–38 (S-palmitoyl cysteine)
Source-annotated extracellular intervals
65–87143–235297–317412–424459–471
65–87; 143–235; 297–317; 412–424; 459–471

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
658723
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
6d2d651faedada597e613239452ed1ba4a4197df1ebf8a6a794827afbb2df2db
14323593
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
03432f9c5c40feafe5bed565d76571a7485ca09d9814b664567cacb663bbe294
29731721
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
caa3902da4af4987c8d220db90ba97b9364f094e3a68b87efde771e9da9311e4
41242413
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
510cdf98592928a450623b92068ca03c8ff2e463b85c8242283af43e84d96fac
45947113
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
70fa839ff42b286204a32c560736827dcaa1d3790c45414b7eef45adbb06e38b
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P43004

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14506254, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}; Multi-pass membrane protein {ECO:0000305}.
transmembrane
TRANSMEM 45..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..259; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 269..296; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 318..339; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 385..411; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 472..493; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003"
topological_domain
TOPO_DOM 1..44; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 65..87; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 109..120; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 143..235; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 260..268; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 297..317; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 340..344; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 376..384; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 412..424; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 459..471; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 494..574; /note="Cytoplasmic"; /evidence="ECO:0000305"
signal_peptide
Not recorded
lipidation
LIPID 38; /note="S-palmitoyl cysteine"; /evidence="ECO:0000250|UniProtKB:P43006"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Excitatory amino acid transporter 2
Protein location
Transmembrane protein
Canonical sequence
P43004 · 574 amino acids
Extracellular region
UniProt annotates extracellular residues 65–87, 143–235, 297–317, 412–424, 459–471.

Expression in normal tissues

RNA specificity
Tissue enriched
RNA distribution
Detected in many
RNA tissue-specific nTPM
brain: 1,024.9
Protein specificity
Tissue enriched
Protein distribution
Detected in some
Immunohistochemistry reliability
Enhanced
Protein tissue-specific intensity
cerebral cortex: 123,025,095.3
Tissue cell-type enrichment
Adrenal gland - Adrenal cortex cells, Breast - Breast glandular cells, Stomach - Chief cells, Testis - Early spermatids, Testis - Late spermatids

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC1A2 · ENSG00000110436 · P43004

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