SLC22A16

Solute carrier family 22 member 16. The canonical sequence contains 577 amino acids.

Sequence and protein regions

Explore the SLC22A16 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median SLC22A16 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples0.5

Other tumor types438 samples0.5

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000004809
UniProt accession: Q86VW1
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 577
Sequence SHA-256: acd531523d9a2aac44c2945acf554b17914786d0cf8a28ba812bfcaf421f4b48

View and select the full canonical sequence

Canonical amino-acid sequence

MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

Sequence positions 1–577

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

23–43 (Helical); 152–172 (Helical); 183–203 (Helical); 214–234 (Helical); 244–264 (Helical); 268–288 (Helical); 359–379 (Helical); 389–409 (Helical); 416–436 (Helical); 441–461 (Helical); 476–496 (Helical); 501–521 (Helical)

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q86VW1

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:20037140}; Multi-pass membrane protein {ECO:0000305}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis. {ECO:0000269|PubMed:12089149}.
transmembrane: TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 441..461; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical"; /evidence="ECO:0000255"
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Solute carrier family 22 member 16
Protein location: Transmembrane protein
Canonical sequence: Q86VW1 · 577 amino acids

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: bone marrow: 19.3; testis: 20.0
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Uncertain
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Testis - Early spermatids
Subcellular location: Plasma membrane, Cytosol

Human Protein Atlas: SLC22A16

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC22A16 · ENSG00000004809 · Q86VW1