Surface AtlasMucinous colon cancer

SLC4A11

Solute carrier family 4 member 11. UniProt annotates extracellular residues 382–394, 431–443, 497–555, 613–640, 705–734, 784–787, 833–836.

Sequence and protein regions

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RNA expression in tumor samples

Median SLC4A11 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples86.9
Other tumor types438 samples73.8
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000088836
UniProt accession
Q8NBS3
Sequence state
available
Canonical sequence
Yes
Length in amino acids
875
Sequence SHA-256
db40369468aab8eac858dd9c9190a36d1385c5c99c5a93d6dadf9b2ad85478d3
View and select the full canonical sequence
Sequence positions 1–875

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
359–381: Helical395–408: Helical414–430: Helical444–467: Helical476–496: Helical556–577: Helical591–612: Helical641–658: Helical684–704: Helical735–759: Helical766–783: Helical788–810: Helical816–832: Helical837–857: Helical
359–381 (Helical); 395–408 (Helical); 414–430 (Helical); 444–467 (Helical); 476–496 (Helical); 556–577 (Helical); 591–612 (Helical); 641–658 (Helical); 684–704 (Helical); 735–759 (Helical); 766–783 (Helical); 788–810 (Helical); 816–832 (Helical); 837–857 (Helical)
Source-annotated domains
1–358: Cytoplasmic382–394: Extracellular409–413: Cytoplasmic431–443: Extracellular468–475: Cytoplasmic497–555: Extracellular578–590: Cytoplasmic613–640: Extracellular659–683: Cytoplasmic705–734: Extracellular760–765: Cytoplasmic784–787: Extracellular811–815: Cytoplasmic833–836: Extracellular858–875: Cytoplasmic
1–358 (Cytoplasmic); 382–394 (Extracellular); 409–413 (Cytoplasmic); 431–443 (Extracellular); 468–475 (Cytoplasmic); 497–555 (Extracellular); 578–590 (Cytoplasmic); 613–640 (Extracellular); 659–683 (Cytoplasmic); 705–734 (Extracellular); 760–765 (Cytoplasmic); 784–787 (Extracellular); 811–815 (Cytoplasmic); 833–836 (Extracellular); 858–875 (Cytoplasmic)
Source-annotated extracellular intervals
382–394431–443497–555613–640705–734784–787833–836
382–394; 431–443; 497–555; 613–640; 705–734; 784–787; 833–836

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
38239413
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
e667200239a4dd4436d25295faf0f35ecb6d4f88124cadb6e59235d44b5256f1
43144313
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
b72948b6820a6106352eda8bdaa10e4c40976df6edbc9e752b39d58b742d9402
49755559
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
eda0c781aa8ae5a1eda3f4d26263b7ea4cedd810eb6e29923a52022141dcb172
61364028
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
d0dfe5c100ca7df19938bdb51f87b91a324d761a0b766dc18fcbee9f1118444c
70573430
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
d4ce50e4234ac2e9a738a3f858dfe5c8d692854a56f0702ccca9ffcd77ecd04b
7847874
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
644016c6064b3b83db88c2f94ba5b761b481c8acc5308753bd19ad7d27dcbd39
8338364
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
e89cf4ec81a52cf56be252b0ad07ebce56c63d8442c2480d79d3498867cba6c1
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q8NBS3

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18024964, ECO:0000269|PubMed:25007886, ECO:0000269|PubMed:31273259}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23813972}; Multi-pass membrane protein {ECO:0000255}.
transmembrane
TRANSMEM 359..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..408; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..467; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 556..577; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 591..612; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 641..658; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 684..704; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 735..759; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 766..783; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 788..810; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 816..832; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 837..857; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..358; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 382..394; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 409..413; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 431..443; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 468..475; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 497..555; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 578..590; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 613..640; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 659..683; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 705..734; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 760..765; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 784..787; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 811..815; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 833..836; /note="Extracellular"; /evidence="ECO:0000305|PubMed:21288032"; TOPO_DOM 858..875; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:21288032"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Solute carrier family 4 member 11
Protein location
Transmembrane protein
Canonical sequence
Q8NBS3 · 875 amino acids
Extracellular region
UniProt annotates extracellular residues 382–394, 431–443, 497–555, 613–640, 705–734, 784–787, 833–836.

Expression in normal tissues

RNA specificity
Group enriched
RNA distribution
Detected in many
RNA tissue-specific nTPM
esophagus: 19.3; kidney: 75.8; salivary gland: 68.1; thyroid gland: 74.6
Protein specificity
Tissue enriched
Protein distribution
Detected in single
Immunohistochemistry reliability
Uncertain
Immunofluorescence reliability
Uncertain
Protein tissue-specific intensity
salivary gland: 71,909.8
Tissue cell-type enrichment
Liver - Vascular endothelial cells, Lung - Respiratory ciliated cells, Minor Salivary Gland - Minor salivary gland ductal cells, Skin - Eccrine sweat gland cells
Subcellular location
Nucleoplasm

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC4A11 · ENSG00000088836 · Q8NBS3

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