SLC8B1

Mitochondrial sodium/calcium exchanger protein. The canonical sequence contains 584 amino acids.

Sequence and protein regions

Explore the SLC8B1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median SLC8B1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples717.4

Other tumor types438 samples690.1

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000089060
UniProt accession: Q6J4K2
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 584
Sequence SHA-256: ae9762e5a0dffda6d39a80d5698f0cb4b49f821c220b514b19978ae1b182a97a

View and select the full canonical sequence

Canonical amino-acid sequence

MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM

Sequence positions 1–584

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–26

Membrane-spanning segments

96–132 (Helical; Name=1); 137–162 (Helical; Name=2); 166–192 (Helical; Name=3); 200–221 (Helical; Name=4); 227–255 (Helical; Name=5); 356–373 (Helical; Name=5); 389–409 (Helical; Name=7); 418–450 (Helical; Name=8); 455–480 (Helical; Name=9); 485–514 (Helical; Name=10); 526–548 (Helical; Name=11); 554–575 (Helical; Name=12)

Source-annotated domains

27–95 (Mitochondrial matrix); 133–136 (Mitochondrial intermembrane); 163–165 (Mitochondrial matrix); 193–199 (Mitochondrial intermembrane); 222–226 (Mitochondrial matrix); 256–355 (Mitochondrial intermembrane); 374–388 (Mitochondrial matrix); 410–417 (Mitochondrial intermembrane); 451–454 (Mitochondrial matrix); 481–484 (Mitochondrial intermembrane); 515–525 (Mitochondrial matrix); 549–553 (Mitochondrial intermembrane); 576–584 (Mitochondrial matrix)

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q6J4K2

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}; Multi-pass membrane protein {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}.
transmembrane: TRANSMEM 96..132; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 137..162; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 166..192; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 200..221; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 227..255; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 356..373; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 389..409; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 418..450; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 455..480; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 485..514; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 526..548; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 554..575; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"
topological_domain: TOPO_DOM 27..95; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 133..136; /note="Mitochondrial intermembrane"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 163..165; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 193..199; /note="Mitochondrial intermembrane"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 222..226; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 256..355; /note="Mitochondrial intermembrane"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 374..388; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 410..417; /note="Mitochondrial intermembrane"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 451..454; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 481..484; /note="Mitochondrial intermembrane"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 515..525; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 549..553; /note="Mitochondrial intermembrane"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TOPO_DOM 576..584; /note="Mitochondrial matrix"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"
signal_peptide: SIGNAL 1..26; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Mitochondrial sodium/calcium exchanger protein
Protein location: Transmembrane protein
Canonical sequence: Q6J4K2 · 584 amino acids

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: adrenal gland: 70.6
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Approved
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Minor Salivary Gland - Minor salivary glandular cells, Pituitary gland - Somatotropes

Human Protein Atlas: SLC8B1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC8B1 · ENSG00000089060 · Q6J4K2