Surface AtlasMucinous colon cancer

SLCO4A1

Solute carrier organic anion transporter family member 4A1. UniProt annotates extracellular residues 125–143, 196–222, 294–307, 401–420, 472–580, 639–671.

Sequence and protein regions

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RNA expression in tumor samples

Median SLCO4A1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples924.3
Other tumor types438 samples1,391.3
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000101187
UniProt accession
Q96BD0
Sequence state
available
Canonical sequence
Yes
Length in amino acids
722
Sequence SHA-256
b57b4616e3364e1fc2a9cc56feee2b3beb83e4d67c007d01efe629fbfddff3ff
View and select the full canonical sequence
Sequence positions 1–722

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
104–124: Helical; Name=1144–164: Helical; Name=2171–195: Helical; Name=3223–253: Helical; Name=4273–293: Helical; Name=5308–332: Helical; Name=6379–400: Helical; Name=7421–444: Helical; Name=8449–471: Helical; Name=9581–603: Helical; Name=10613–638: Helical; Name=11672–689: Helical; Name=12
104–124 (Helical; Name=1); 144–164 (Helical; Name=2); 171–195 (Helical; Name=3); 223–253 (Helical; Name=4); 273–293 (Helical; Name=5); 308–332 (Helical; Name=6); 379–400 (Helical; Name=7); 421–444 (Helical; Name=8); 449–471 (Helical; Name=9); 581–603 (Helical; Name=10); 613–638 (Helical; Name=11); 672–689 (Helical; Name=12)
Source-annotated domains
1–103: Cytoplasmic125–143: Extracellular165–170: Cytoplasmic196–222: Extracellular254–272: Cytoplasmic294–307: Extracellular333–378: Cytoplasmic401–420: Extracellular445–448: Cytoplasmic472–580: Extracellular604–612: Cytoplasmic639–671: Extracellular690–722: Cytoplasmic
1–103 (Cytoplasmic); 125–143 (Extracellular); 165–170 (Cytoplasmic); 196–222 (Extracellular); 254–272 (Cytoplasmic); 294–307 (Extracellular); 333–378 (Cytoplasmic); 401–420 (Extracellular); 445–448 (Cytoplasmic); 472–580 (Extracellular); 604–612 (Cytoplasmic); 639–671 (Extracellular); 690–722 (Cytoplasmic)
Source-annotated extracellular intervals
125–143196–222294–307401–420472–580639–671
125–143; 196–222; 294–307; 401–420; 472–580; 639–671

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
12514319
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
4303bfbe895bf05ceada9969c2433e402b511ccbc7ff1bfd9a24b8d9cd5b5377
19622227
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
a16d65e7be41453c5262f83e2abb4434d8b1eaaf67eb83b325a0460ac5c10cea
29430714
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
17d767784219f67020a3bbb5d2e728f7320e375365bf6189578583ae6a6a1a48
40142020
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
d921bcc9d99241750809cd0239bd18f78f19f4cb91f384912db9582839aa89fe
472580109
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
a55a51e193a1468ceaae643093c4a240d99e1db2f1b7e140145fa3c3ca589922
63967133
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
9da917b2e186e4ed25a4726fcf9cbb69e3f019566363ed5ed4dfb9c1b32955f9
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q96BD0

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:30343886}; Multi-pass membrane protein {ECO:0000255}.
transmembrane
TRANSMEM 104..124; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 171..195; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 223..253; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 308..332; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 379..400; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 421..444; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 449..471; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 581..603; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 613..638; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 672..689; /note="Helical; Name=12"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..103; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 125..143; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 165..170; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 196..222; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 254..272; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 294..307; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 333..378; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 401..420; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 445..448; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 472..580; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 604..612; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 639..671; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 690..722; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Solute carrier organic anion transporter family member 4A1
Protein location
Transmembrane protein
Canonical sequence
Q96BD0 · 722 amino acids
Extracellular region
UniProt annotates extracellular residues 125–143, 196–222, 294–307, 401–420, 472–580, 639–671.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
lung: 56.0
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Uncertain
Immunofluorescence reliability
Supported
Subcellular location
Cell Junctions

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLCO4A1 · ENSG00000101187 · Q96BD0

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