Surface AtlasMucinous colon cancer

SSTR2

Somatostatin receptor type 2. UniProt annotates extracellular residues 1–43, 104–118, 182–207, 279–288.

Sequence and protein regions

Explore the SSTR2 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median SSTR2 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples8.0
Other tumor types438 samples6.6
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000180616
UniProt accession
P30874
Sequence state
available
Canonical sequence
Yes
Length in amino acids
369
Sequence SHA-256
6001055d0866d9ee2c225eb36b22f1f56726909686411070689b585515e38d7b
View and select the full canonical sequence
Sequence positions 1–369

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
44–67: Helical; Name=179–103: Helical; Name=2119–138: Helical; Name=3162–181: Helical; Name=4208–229: Helical; Name=5254–278: Helical; Name=6289–303: Helical; Name=7
44–67 (Helical; Name=1); 79–103 (Helical; Name=2); 119–138 (Helical; Name=3); 162–181 (Helical; Name=4); 208–229 (Helical; Name=5); 254–278 (Helical; Name=6); 289–303 (Helical; Name=7)
Source-annotated domains
1–43: Extracellular68–78: Cytoplasmic104–118: Extracellular139–161: Cytoplasmic182–207: Extracellular230–253: Cytoplasmic279–288: Extracellular304–369: Cytoplasmic
1–43 (Extracellular); 68–78 (Cytoplasmic); 104–118 (Extracellular); 139–161 (Cytoplasmic); 182–207 (Extracellular); 230–253 (Cytoplasmic); 279–288 (Extracellular); 304–369 (Cytoplasmic)
Lipid attachment sites
328–328: S-palmitoyl cysteine
328–328 (S-palmitoyl cysteine)
Source-annotated extracellular intervals
1–43104–118182–207279–288
1–43; 104–118; 182–207; 279–288

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
14343
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
eb988463421cbe6917880a9b8da417c71ae8b4ba33be2fb01c08fabe5e030a9a
10411815
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
4ac7c3133c1c62690c8314e09762bb494b98fbea1020aabd17f304c4304a1d4f
18220726
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
8a13ad335b6613ecf191363443d3595a3cca987bc043a4c3609b702f627c8f9c
27928810
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
19f64d230191dce9feb402c8d535636f24b3b1fd9112a91ada16cf3cd830ca11
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

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Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P30874

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subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
transmembrane
TRANSMEM 44..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..103; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 162..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 208..229; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..303; /note="Helical; Name=7"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..43; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 68..78; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 104..118; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 139..161; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 182..207; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 230..253; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 279..288; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 304..369; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
Not recorded
lipidation
LIPID 328; /note="S-palmitoyl cysteine"; /evidence="ECO:0000255"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Somatostatin receptor type 2
Protein location
Transmembrane protein
Canonical sequence
P30874 · 369 amino acids
Extracellular region
UniProt annotates extracellular residues 1–43, 104–118, 182–207, 279–288.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
brain: 17.7
Protein specificity
Tissue enriched
Protein distribution
Detected in single
Immunohistochemistry reliability
Uncertain
Immunofluorescence reliability
Supported
Protein tissue-specific intensity
cerebral cortex: 161,119.5
Tissue cell-type enrichment
Breast - Endothelial cells, Pituitary gland - Thyrotropes, Prostate - Fibroblasts, Stomach - Chief cells
Subcellular location
Cytosol

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SSTR2 · ENSG00000180616 · P30874

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