Surface AtlasMucinous colon cancer

TGFA

Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha. UniProt annotates extracellular residues 24–98.

Sequence and protein regions

Explore the TGFA sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median TGFA RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples558.3
Other tumor types438 samples437.0
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000163235
UniProt accession
P01135
Sequence state
available
Canonical sequence
Yes
Length in amino acids
160
Sequence SHA-256
d18a89bf2daa95c4bd4d581664e00678a12e814a203cbd84fac5e9425989754c
View and select the full canonical sequence
Sequence positions 1–160

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide
1–23
1–23
Membrane-spanning segments
99–124: Helical
99–124 (Helical)
Source-annotated domains
24–98: Extracellular125–160: Cytoplasmic
24–98 (Extracellular); 125–160 (Cytoplasmic)
Lipid attachment sites
153–153: S-palmitoyl cysteine154–154: S-palmitoyl cysteine
153–153 (S-palmitoyl cysteine); 154–154 (S-palmitoyl cysteine)
Source-annotated extracellular intervals
24–98
24–98

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
249875
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
16efe0f6183652c9f84212eed358c9ce9cc9249ddf8bc768dd4a60217eaba4a3
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

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Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P01135

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subcellular_location
SUBCELLULAR LOCATION: [Transforming growth factor alpha]: Secreted, extracellular space.; SUBCELLULAR LOCATION: [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
transmembrane
TRANSMEM 99..124; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 24..98; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 125..160; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
SIGNAL 1..23; /evidence="ECO:0000255"
lipidation
LIPID 153; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:8910478"; LIPID 154; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:8910478"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha
Protein location
Transmembrane protein
Canonical sequence
P01135 · 160 amino acids
Extracellular region
UniProt annotates extracellular residues 24–98.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
brain: 24.5; esophagus: 24.0
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Approved
Immunofluorescence reliability
Approved
Tissue cell-type enrichment
Spleen - Macrophages, Stomach - Gastric mucous cells, Testis - Early spermatids, Testis - Late spermatids
Subcellular location
Vesicles

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TGFA · ENSG00000163235 · P01135

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