TNFRSF8

Tumor necrosis factor receptor superfamily member 8. UniProt annotates extracellular residues 19–385.

Sequence and protein regions

Explore the TNFRSF8 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median TNFRSF8 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples13.5

Other tumor types438 samples12.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000120949
UniProt accession: P28908
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 595
Sequence SHA-256: 9a61bc3ff7833fc4874fd53fce48683d782bd50295d5d6540448c418af0cf4f1

View and select the full canonical sequence

Canonical amino-acid sequence

MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK

Sequence positions 1–595

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–18

Membrane-spanning segments

386–406 (Helical)

Source-annotated domains

19–385 (Extracellular); 407–595 (Cytoplasmic)

Source-annotated extracellular intervals

19–385

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
19	385	367	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 37ac06febc43af19fffae430a820c16e0ac16424e8cae522d5018b1412e4116a Amino-acid sequence for this intervalFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P28908

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8391931, ECO:0000305|PubMed:8999898}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8839832}.
transmembrane: TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 19..385; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 407..595; /note="Cytoplasmic"; /evidence="ECO:0000305"
signal_peptide: SIGNAL 1..18
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Tumor necrosis factor receptor superfamily member 8
Protein location: Transmembrane protein
Canonical sequence: P28908 · 595 amino acids
Extracellular region: UniProt annotates extracellular residues 19–385.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in some
RNA tissue-specific nTPM: adipose tissue: 5.1
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Minor Salivary Gland - Endothelial cells
Subcellular location: Plasma membrane

Human Protein Atlas: TNFRSF8

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TNFRSF8 · ENSG00000120949 · P28908