Surface AtlasMucinous colon cancer

TRPV6

Transient receptor potential cation channel subfamily V member 6. UniProt annotates extracellular residues 389–425, 484–489, 553–565, 586–596.

Sequence and protein regions

Explore the TRPV6 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median TRPV6 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples4.5
Other tumor types438 samples0.7
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000165125
UniProt accession
Q9H1D0
Sequence state
available
Canonical sequence
Yes
Length in amino acids
765
Sequence SHA-256
de54b9165094fbbc9ce6aea67a4d5a27fd2bb142520dfc52151e11ec44f23c69
View and select the full canonical sequence
Sequence positions 1–765

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
368–388: Helical426–448: Helical464–483: Helical490–509: Helical530–552: Helical597–617: Helical
368–388 (Helical); 426–448 (Helical); 464–483 (Helical); 490–509 (Helical); 530–552 (Helical); 597–617 (Helical)
Source-annotated domains
1–367: Cytoplasmic389–425: Extracellular449–463: Cytoplasmic484–489: Extracellular510–529: Cytoplasmic553–565: Extracellular586–596: Extracellular618–765: Cytoplasmic
1–367 (Cytoplasmic); 389–425 (Extracellular); 449–463 (Cytoplasmic); 484–489 (Extracellular); 510–529 (Cytoplasmic); 553–565 (Extracellular); 586–596 (Extracellular); 618–765 (Cytoplasmic)
Source-annotated extracellular intervals
389–425484–489553–565586–596
389–425; 484–489; 553–565; 586–596

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
38942537
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
53beda23cec562ba575d55315705d4504992c466dfcc0a07ad873368b8bae4b5
4844896
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
f28e73d2ada6d04276178469fedd7641c3d74f208e923cf7c05984c1699e7665
55356513
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
05bd75bfa3935cbbdf06f95132951b5e352305d520efac2d364dad041e0c7deb
58659611
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
8a33cc477683d25b042f2abd277e526fec0574e02cdabd0b5ce4594464009474
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q9H1D0

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}; Multi-pass membrane protein {ECO:0000269|PubMed:29258289}.
transmembrane
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000305|PubMed:29258289"; TRANSMEM 426..448; /note="Helical"; /evidence="ECO:0000305|PubMed:29258289"; TRANSMEM 464..483; /note="Helical"; /evidence="ECO:0000305|PubMed:29258289"; TRANSMEM 490..509; /note="Helical"; /evidence="ECO:0000305|PubMed:29258289"; TRANSMEM 530..552; /note="Helical"; /evidence="ECO:0000305|PubMed:29258289"; TRANSMEM 597..617; /note="Helical"; /evidence="ECO:0000305|PubMed:29258289"
topological_domain
TOPO_DOM 1..367; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 389..425; /note="Extracellular"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 449..463; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 484..489; /note="Extracellular"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 510..529; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 553..565; /note="Extracellular"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 586..596; /note="Extracellular"; /evidence="ECO:0000305|PubMed:29258289"; TOPO_DOM 618..765; /note="Cytoplasmic"; /evidence="ECO:0000305|PubMed:29258289"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Transient receptor potential cation channel subfamily V member 6
Protein location
Transmembrane protein
Canonical sequence
Q9H1D0 · 765 amino acids
Extracellular region
UniProt annotates extracellular residues 389–425, 484–489, 553–565, 586–596.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
pancreas: 36.4; prostate: 22.1; salivary gland: 65.3
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Approved
Tissue cell-type enrichment
Adipose visceral - Mesothelial cells, Liver - Cholangiocytes, Pituitary gland - Lactotropes, Prostate - Prostate glandular cells, Testis - Late spermatids

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TRPV6 · ENSG00000165125 · Q9H1D0

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