VSIG1

V-set and immunoglobulin domain-containing protein 1. UniProt annotates extracellular residues 22–232.

Sequence and protein regions

Explore the VSIG1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median VSIG1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples9.0

Other tumor types438 samples5.1

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000101842
UniProt accession: Q86XK7
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 387
Sequence SHA-256: 75372d1e810059ce73a76efa4867008a6a6a521d2e354fe5a21b375c60ac89e8

View and select the full canonical sequence

Canonical amino-acid sequence

MVFAFWKVFLILSCLAGQVSVVQVTIPDGFVNVTVGSNVTLICIYTTTVASREQLSIQWSFFHKKEMEPISIYFSQGGQAVAIGQFKDRITGSNDPGNASITISHMQPADSGIYICDVNNPPDFLGQNQGILNVSVLVKPSKPLCSVQGRPETGHTISLSCLSALGTPSPVYYWHKLEGRDIVPVKENFNPTTGILVIGNLTNFEQGYYQCTAINRLGNSSCEIDLTSSHPEVGIIVGALIGSLVGAAIIISVVCFARNKAKAKAKERNSKTIAELEPMTKINPRGESEAMPREDATQLEVTLPSSIHETGPDTIQEPDYEPKPTQEPAPEPAPGSEPMAVPDLDIELELEPETQSELEPEPEPEPESEPGVVVEPLSEDEKGVVKA

Sequence positions 1–387

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

233–253 (Helical)

Source-annotated domains

22–232 (Extracellular); 254–387 (Cytoplasmic)

Source-annotated extracellular intervals

22–232

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	232	211	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 3d97ab631cac68d80cddc01cd343baf3bb0b432939fb6d55b8755a8d7edb020b Amino-acid sequence for this intervalVQVTIPDGFVNVTVGSNVTLICIYTTTVASREQLSIQWSFFHKKEMEPISIYFSQGGQAVAIGQFKDRITGSNDPGNASITISHMQPADSGIYICDVNNPPDFLGQNQGILNVSVLVKPSKPLCSVQGRPETGHTISLSCLSALGTPSPVYYWHKLEGRDIVPVKENFNPTTGILVIGNLTNFEQGYYQCTAINRLGNSSCEIDLTSSHPE

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q86XK7

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
transmembrane: TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..232; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 254..387; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)