VTCN1

V-set domain-containing T-cell activation inhibitor 1. UniProt annotates extracellular residues 25–259.

Sequence and protein regions

Explore the VTCN1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median VTCN1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples4.8

Other tumor types438 samples0.9

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000134258
UniProt accession: Q7Z7D3
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 282
Sequence SHA-256: 4ae8545c495dbf569bad2e2c1f9e18fc02fdadf177069eaa45ec0495879c17e3

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Canonical amino-acid sequence

MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK

Sequence positions 1–282

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–24

Membrane-spanning segments

260–280 (Helical)

Source-annotated domains

25–259 (Extracellular); 281–282 (Cytoplasmic)

Source-annotated extracellular intervals

25–259

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
25	259	235	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 4a99d696a54c4c51da3474c260a166cfa7f5de52c39bf4ef552e44fc20dde332 Amino-acid sequence for this intervalLIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKAS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q7Z7D3

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
transmembrane: TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 25..259; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 281..282; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..24; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: V-set domain-containing T-cell activation inhibitor 1
Protein location: Transmembrane protein
Canonical sequence: Q7Z7D3 · 282 amino acids
Extracellular region: UniProt annotates extracellular residues 25–259.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: breast: 94.8; fallopian tube: 30.5; pancreas: 28.4
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: fallopian tube: 52,545.6
Tissue cell-type enrichment: Heart muscle - Cardiomyocytes, Lung - Respiratory ciliated cells, Prostate - Urothelial cells
Subcellular location: Plasma membrane

Human Protein Atlas: VTCN1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

VTCN1 · ENSG00000134258 · Q7Z7D3